Literature summary for 2.1.1.72 extracted from

Evdokimov, A.A.; Zinoviev, V.V.; Malygin, E.G.; Schlagman, S.L.; Hattman, S.
Bacteriophage T4 Dam DNA-[N6-adenine]methyltransferase. Kinetic evidence for a catalytically essential conformational change in the ternary complex (2002), J. Biol. Chem., 277, 279-286.

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Activating Compound

Activating Compound	Comment	Organism	Structure
S-adenosyl-L-methionine	stimulates at increasing concentrations	Tequatrovirus T4

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	reduction of methylation rate at high concentrations of the substrate 20-mer DNA duplex	Tequatrovirus T4
S-adenosyl-L-homocysteine	product inhibition	Tequatrovirus T4
sinefungin	-	Tequatrovirus T4

Organism

Organism	UniProt	Comment	Textmining
Tequatrovirus T4	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
S-adenosyl-L-methionine + adenine in DNA = S-adenosyl-L-homocysteine + N6-methyladenine in DNA	steady-state-ordered bi-bi mechanism in which the order of substrate binding and product release is S-adenosyl-L-methionine, DNA, DNAMe, S-adenosyl-L-homocysteine	Tequatrovirus T4	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + DNA adenine	the enzyme mediates methyl group transfer reaction from S-adenosyl-L-methionine to adenine in the palindromic recognition sequence, GATC, of a 20-mer oligonucleotide duplex	Tequatrovirus T4	S-adenosyl-L-homocysteine + DNA 6-methylaminopurine	-	?

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Release 2023.1 (January 2023)