Application | Comment | Organism |
---|---|---|
medicine | TPMT activity is a good prediction factor for the toxicity and efficacy of the antileukemic thiopurine therapy | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A154T | mutant shows decreased TPMT activity | Homo sapiens |
A154T/Y240C | mutant shows decreased TPMT activity | Homo sapiens |
A167G | mutant shows decreased TPMT activity | Homo sapiens |
A80P | mutant shows decreased TPMT activity | Homo sapiens |
C132Y | mutant shows decreased TPMT activity | Homo sapiens |
C212R | mutant shows decreased TPMT activity | Homo sapiens |
E28V | mutant shows decreased TPMT activity | Homo sapiens |
G144R | mutant shows decreased TPMT activity | Homo sapiens |
G36S | mutant shows decreased TPMT activity | Homo sapiens |
G71R | mutant shows decreased TPMT activity | Homo sapiens |
H227Q | mutant shows decreased TPMT activity | Homo sapiens |
K119T | mutant shows decreased TPMT activity | Homo sapiens |
K122T | mutant shows normal TPMT activity | Homo sapiens |
K238E | mutant shows decreased TPMT activity | Homo sapiens |
L49S | mutant shows decreased TPMT activity | Homo sapiens |
L69V | mutant shows decreased TPMT activity | Homo sapiens |
Q42E | mutant shows decreased TPMT activity | Homo sapiens |
R163H | mutant shows decreased TPMT activity | Homo sapiens |
R163P | mutant shows decreased TPMT activity | Homo sapiens |
R215H | mutant shows decreased TPMT activity | Homo sapiens |
S125L | mutant shows decreased TPMT activity | Homo sapiens |
Y180F | mutant shows decreased TPMT activity | Homo sapiens |
Y240C | mutant shows decreased TPMT activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | low levels of methionine can result in low S-adenosyl-L-methionine levels and consequently decreased TPMT activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | S-adenosyl-L-methionine and sinefungin prevent degradation of TPMT by stabilizing ist native structure | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | S-adenosyl-L-methionine and sinefungin prevent degradation of TPMT by stabilizing ist native structure | Homo sapiens | ? | - |
? | |
S-adenosyl-L-methionine + 6-mercaptopurine | TPMT deactivates 6-mercaptopurine by methylation | Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPMT | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | S-adenosyl-L-methionine has no effect on TPMT mRNA expression | additional information |
Homo sapiens | smokers have significantly higher TPMT activity than nonsmokers | up |