Activating Compound | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | S-adenosyl-L-methionine acts as a positive modulator of TPMT activity, the effect of S-adenosyl-L-methionine appears to be restricted to protein stabilisation rather than an increase of TPMT expression | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-Mercaptopurine | TPMT activity and protein levels are diminished in cells incubated with 6-mercaptopurine | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lymphoblast | - |
Homo sapiens | - |
MOLT cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 6-mercaptopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine | - |
? | |
S-adenosyl-L-methionine + thioinosine monophosphate | - |
Homo sapiens | S-adenosyl-L-homocysteine + methylthioinosine monophosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thiopurine methyltransferase | - |
Homo sapiens |
TPMT | - |
Homo sapiens |