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Literature summary for 2.1.1.67 extracted from

  • Fargher, E.A.; Tricker, K.; Newman, W.; Elliott, R.; Roberts, S.A.; Shaffer, J.L.; Bruce, I.; Payne, K.
    Current use of pharmacogenetic testing: a national survey of thiopurine methyltransferase testing prior to azathioprine prescription (2007), J. Clin. Pharm. Ther., 32, 187-195.
    View publication on PubMed

Application

Application Comment Organism
medicine thiopurine methyltransferase is a genetically moderated key enzyme involved in the metabolism of azathioprine that can be used to stratify individuals into different levels of risk of developing neutropaenia Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-mercaptopurine
-
Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
?
S-adenosyl-L-methionine + a thiopurine
-
Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
?
S-adenosyl-L-methionine + azathioprine
-
Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ?
-
?

Synonyms

Synonyms Comment Organism
thiopurine methyltransferase
-
Homo sapiens
TPMT
-
Homo sapiens