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Literature summary for 2.1.1.67 extracted from

  • Jones, T.S.; Yang, W.; Evans, W.E.; Relling, M.V.
    Using HapMap tools in pharmacogenomic discovery: the thiopurine methyltransferase polymorphism (2007), Clin. Pharmacol. Ther., 81, 729-734.
    View publication on PubMed
Search for more literature for 2.1.1.67

Protein Variants

Protein Variants Comment Organism
TPMT*3A polymorphism, single nucleotide substitutions G460A and A719G Homo sapiens
TPMT*3C polymorphism, single nucleotide substitution A719G Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
 S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lymphoblastoid cell line
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
S-adenosyl-L-methionine + 6-thioguanine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylthioguanine
-
 ?
S-adenosyl-L-methionine + a thiopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
S-adenosyl-L-methionine + azathioprine azathioprine is converted via a non-enzymatic reaction to mercaptopurine, which is subsequently metabolized through TPMT Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ?
-
 ?

Synonyms

Synonyms Comment Organism
thiopurine methyltransferase
-
 Homo sapiens
TPMT
-
 Homo sapiens