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Literature summary for 2.1.1.67 extracted from
- Duplex pyrosequencing of the TPMT3C and TPMT6 alleles in Korean and Vietnamese populations (2008), Clin. Chim. Acta, 398, 82-85.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | individuals with decreased TPMT activity are at high risk of fatal adverse reactions if treated with conventional thiopurine doses | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| 238G>C | TPMT variant | Homo sapiens |
| 460G>A | TPMT variant | Homo sapiens |
| 539A>T | TPMT variant | Homo sapiens |
| 719A>G | TPMT variant | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + a thiopurine | Homo sapiens | - |
S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + 6-mercaptopurine | - |
Homo sapiens | ? | - |
? | |
| S-adenosyl-L-methionine + 6-thioguanine | - |
Homo sapiens | ? | - |
? | |
| S-adenosyl-L-methionine + a thiopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? | |
| S-adenosyl-L-methionine + azathioprine | - |
Homo sapiens | ? | - |
? | |
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Release 2023.1 (January 2023)
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