Application | Comment | Organism |
---|---|---|
analysis | monitoring of 6-thiopurine S-methyltransferase activity is especially important when patients are treated with 6-thiopurine drugs (drugs in treatment of acute lymphoblastic leukemia), since severe bone marrow toxicity may be induced if patients have deficient 6-thiopurine S-methyltransferase activity. The HPLC-based method enables the rapid screening of 6-6-thiopurine S-methyltransferase activities in patients treated with 6-thiopurines | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00665 | - |
S-adenosyl-L-methionine | Molt-F4 cell | Homo sapiens | |
0.0119 | - |
S-adenosyl-L-methionine | erythrocyte | Homo sapiens | |
0.0164 | - |
S-adenosyl-L-methionine | peripheral blood mononuclear cell | Homo sapiens | |
0.54 | - |
6-Mercaptopurine | erythrocyte | Homo sapiens | |
0.65 | - |
6-Mercaptopurine | Molt-F4 cell | Homo sapiens | |
0.85 | - |
6-Mercaptopurine | peripheral blood mononuclear cell | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
MOLT-4F cell | - |
Homo sapiens | - |
peripheral blood mononuclear cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 6-mercaptopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
6-thiopurine S-methyltransferase | - |
Homo sapiens |
TPMT | - |
Homo sapiens |