Application | Comment | Organism |
---|---|---|
medicine | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
baculovirus expressed | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,8-dihydroxy-6-mercaptopurine | - |
Homo sapiens | |
2-Hydroxy-6-mercaptopurine | - |
Homo sapiens | |
6-thioguanine | mixed inhibitor of 6-mercaptopurine methylation | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.38 | - |
6-Mercaptopurine | kidney enzyme | Homo sapiens | |
0.58 | - |
6-Mercaptopurine | liver enzyme | Homo sapiens | |
0.99 | - |
6-Mercaptopurine | recombinant enzyme, baculovirus expressed | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + a thiopurine | Homo sapiens | - |
S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 6-mercaptopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine | - |
? | |
S-adenosyl-L-methionine + a thiopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.45 | - |
6-thioguanine | - |
Homo sapiens | |
0.9 | - |
6-thioguanine | - |
Homo sapiens |