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Literature summary for 2.1.1.67 extracted from

  • Remy, C.N.
    Metabolism of thiopyrimidines and thiopurines (1963), J. Biol. Chem., 238, 1078-1084.
    View publication on PubMed
Search for more literature for 2.1.1.67

Inhibitors

Inhibitors Comment Organism Structure
2,3-Dithiopropanol
-
 Mus musculus
2,3-Dithiopropanol
-
 Rattus norvegicus
2,4-dithiopyrimidine
-
 Mus musculus
2,4-dithiopyrimidine
-
 Rattus norvegicus
2-amino-6-thiopurine
-
 Mus musculus
2-amino-6-thiopurine
-
 Rattus norvegicus
2-mercaptoethanol
-
 Mus musculus
2-mercaptoethanol
-
 Rattus norvegicus
2-methylthio-4-hydroxypyrimidine 1.8 mM, 45% inhibition Mus musculus
2-methylthio-4-hydroxypyrimidine 1.8 mM, 45% inhibition Rattus norvegicus
2-Methylthiouracil
-
 Mus musculus
2-Methylthiouracil
-
 Rattus norvegicus
5-methyl-2,4-dithiopyrimidine
-
 Mus musculus
5-methyl-2,4-dithiopyrimidine
-
 Rattus norvegicus
6-hydroxy-2-thiopurine
-
 Mus musculus
6-hydroxy-2-thiopurine
-
 Rattus norvegicus
6-methylthiopurine
-
 Mus musculus
6-methylthiopurine
-
 Rattus norvegicus
glutathione
-
 Mus musculus
glutathione
-
 Rattus norvegicus
L-cysteine 1.8 mM, 50% inhibition Mus musculus
L-cysteine 1.8 mM, 50% inhibition Rattus norvegicus
L-homocysteine
-
 Mus musculus
L-homocysteine
-
 Rattus norvegicus
L-homocysteine thiolactone
-
 Mus musculus
L-homocysteine thiolactone
-
 Rattus norvegicus
S-adenosyl-L-methionine
-
 Mus musculus
S-adenosyl-L-methionine
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.2
-
 6-Thiopurine
-
 Mus musculus
1.7
-
 2-Thiouracil
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a thiopurine Mus musculus specific for S-adenosyl-L-methionine S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
S-adenosyl-L-methionine + a thiopurine Rattus norvegicus specific for S-adenosyl-L-methionine S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
S-adenosyl-L-methionine + a thiopurine Mus musculus Swiss-Webster specific for S-adenosyl-L-methionine S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 mouse
-
Mus musculus
-
 Swiss-Webster
-
Mus musculus Swiss-Webster
-
 Swiss-Webster
-
Rattus norvegicus
-
 rat, Sprague-Dawley
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Mus musculus
-
kidney
-
 Rattus norvegicus
-
liver
-
 Mus musculus
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 2,8-dihydroxy-6-thiopurine
-
 Mus musculus S-adenosyl-L-homocysteine + 2,8-dihydroxy-6-methylthiopurine
-
 ?
S-adenosyl-L-methionine + 2,8-dihydroxy-6-thiopurine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + 2,8-dihydroxy-6-methylthiopurine
-
 ?
S-adenosyl-L-methionine + 2-amino-6-thiopurine
-
 Mus musculus S-adenosyl-L-homocysteine + 2-amino-6-methylthiopurine
-
 ?
S-adenosyl-L-methionine + 2-amino-6-thiopurine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + 2-amino-6-methylthiopurine
-
 ?
S-adenosyl-L-methionine + 2-thiothymine
-
 Mus musculus S-adenosyl-L-homocysteine + 2-methylthiothymine
-
 ?
S-adenosyl-L-methionine + 2-thiothymine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + 2-methylthiothymine
-
 ?
S-adenosyl-L-methionine + 2-thiothymine
-
 Mus musculus Swiss-Webster S-adenosyl-L-homocysteine + 2-methylthiothymine
-
 ?
S-adenosyl-L-methionine + 2-thiouracil
-
 Mus musculus S-adenosyl-L-homocysteine + thiouracil-2-S-methylether
-
 ?
S-adenosyl-L-methionine + 2-thiouracil
-
 Rattus norvegicus S-adenosyl-L-homocysteine + thiouracil-2-S-methylether
-
 ?
S-adenosyl-L-methionine + 2-thiouracil
-
 Mus musculus Swiss-Webster S-adenosyl-L-homocysteine + thiouracil-2-S-methylether
-
 ?
S-adenosyl-L-methionine + 6-thioguanine
-
 Mus musculus S-adenosyl-L-homocysteine + 6-methylthioguanine
-
 ?
S-adenosyl-L-methionine + 6-thioguanine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + 6-methylthioguanine
-
 ?
S-adenosyl-L-methionine + 6-thioguanine
-
 Mus musculus Swiss-Webster S-adenosyl-L-homocysteine + 6-methylthioguanine
-
 ?
S-adenosyl-L-methionine + 6-thiopurine preferred substrate Mus musculus S-adenosyl-L-homocysteine + 6-methylthiopurine
-
 ?
S-adenosyl-L-methionine + 6-thiopurine preferred substrate Rattus norvegicus S-adenosyl-L-homocysteine + 6-methylthiopurine
-
 ?
S-adenosyl-L-methionine + 6-thiopurine preferred substrate Mus musculus Swiss-Webster S-adenosyl-L-homocysteine + 6-methylthiopurine
-
 ?
S-adenosyl-L-methionine + 6-thiouric acid
-
 Mus musculus S-adenosyl-L-homocysteine + 6-methylthiouric acid
-
 ?
S-adenosyl-L-methionine + 6-thiouric acid
-
 Rattus norvegicus S-adenosyl-L-homocysteine + 6-methylthiouric acid
-
 ?
S-adenosyl-L-methionine + a thiopurine specific for S-adenosyl-L-methionine Mus musculus S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
S-adenosyl-L-methionine + a thiopurine specific for S-adenosyl-L-methionine Rattus norvegicus S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
S-adenosyl-L-methionine + a thiopurine specific for S-adenosyl-L-methionine Mus musculus Swiss-Webster S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
45 56 heat inactivation, 23% of the activity is lost after 20 min at 45°C, 95% activity is lost after 6 min at 56°C Mus musculus
45 56 heat inactivation, 23% of the activity is lost after 20 min at 45°C, 95% activity is lost after 6 min at 56°C Rattus norvegicus