Literature summary for 2.1.1.64 extracted from

Poon, W.W.; Barkovich, R.J.; Hsu, A.Y.; Frankel, A.; Lee, P.T.; Sheperd, J.N.; Myles, D.C.; Clarke, C.F.
Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis (1999), J. Biol. Chem., 274, 21665-21672.

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Cloned(Commentary)

Cloned (Comment)	Organism
rat COQ3 gene restores O-methyltransferase activity in coq3 null mutant yeast	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	the Coq3 polypeptide is peripherally associated with the matrix side of the inner membrane of yeast mitochondria	Saccharomyces cerevisiae	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + 3-demethylubiquinol-6	Saccharomyces cerevisiae	the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-6 in Saccharomyces cerevisiae, 1. the methylation of 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-6	S-adenosyl-L-homocysteine + ubiquinol-6	-	?
S-adenosyl-L-methionine + 3-demethylubiquinol-8	Escherichia coli	the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-8 in Escherichia coli, 1. the methylation of 3,4-dihydroxy-5-all-trans-octaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-8	S-adenosyl-L-homocysteine + ubiquinol-8	-	?
S-adenosyl-L-methionine + 3-demethylubiquinol-9	Rattus norvegicus	the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-9 in Rattus norvegicus, 1. the methylation of 3,4-dihydroxy-5-all-trans-octaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-9	S-adenosyl-L-homocysteine + ubiquinol-9	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-
Rattus norvegicus	Q63159	-	-
Saccharomyces cerevisiae	P27680	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + 3-demethylubiquinol-3	i.e. 5-(2E,6E)-farnesyl-2-hydroxy-3-methoxy-6-methyl-1,4-benzoquinone	Escherichia coli	S-adenosyl-L-homocysteine + ubiquinol-3	-	?
S-adenosyl-L-methionine + 3-demethylubiquinol-3	i.e. 5-(2E,6E)-farnesyl-2-hydroxy-3-methoxy-6-methyl-1,4-benzoquinone	Saccharomyces cerevisiae	S-adenosyl-L-homocysteine + ubiquinol-3	-	?
S-adenosyl-L-methionine + 3-demethylubiquinol-3	i.e. 5-(2E,6E)-farnesyl-2-hydroxy-3-methoxy-6-methyl-1,4-benzoquinone, in vitro assay	Rattus norvegicus	S-adenosyl-L-homocysteine + ubiquinol-3	-	?
S-adenosyl-L-methionine + 3-demethylubiquinol-6	the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-6 in Saccharomyces cerevisiae, 1. the methylation of 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-6	Saccharomyces cerevisiae	S-adenosyl-L-homocysteine + ubiquinol-6	-	?
S-adenosyl-L-methionine + 3-demethylubiquinol-8	the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-8 in Escherichia coli, 1. the methylation of 3,4-dihydroxy-5-all-trans-octaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-8	Escherichia coli	S-adenosyl-L-homocysteine + ubiquinol-8	-	?
S-adenosyl-L-methionine + 3-demethylubiquinol-9	the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-9 in Rattus norvegicus, 1. the methylation of 3,4-dihydroxy-5-all-trans-octaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-9	Rattus norvegicus	S-adenosyl-L-homocysteine + ubiquinol-9	-	?

Synonyms

Synonyms	Comment	Organism
COQ3	-	Saccharomyces cerevisiae
COQ3	-	Rattus norvegicus
UbiG	-	Escherichia coli

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7	-	assay at	Escherichia coli
7	-	assay at	Saccharomyces cerevisiae
7	-	assay at	Rattus norvegicus

General Information

General Information	Comment	Organism
malfunction	rat COQ3 gene restores O-methyltransferase activity in coq3 null mutant yeast	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)