Literature summary for 2.1.1.63 extracted from

Senthong, P.; Millington, C.L.; Wilkinson, O.J.; Marriott, A.S.; Watson, A.J.; Reamtong, O.; Eyers, C.E.; Williams, D.M.; Margison, G.P.; Povey, A.C.
The nitrosated bile acid DNA lesion O6-carboxymethylguanine is a substrate for the human DNA repair protein O6-methylguanine-DNA methyltransferase (2013), Nucleic Acids Res., 41, 3047-3055.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
DNA (containing 6-O-carboxymethylguanine)	-	Homo sapiens
DNA (containing 6-O-methylguanine)	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
DNA (containing 6-O-carboxymethylguanine) + protein L-cysteine	Homo sapiens	-	DNA (without 6-O-carboxymethylguanine) + protein S-carboxymethyl-L-cysteine	-	?
DNA (containing 6-O-methylguanine) + protein L-cysteine	Homo sapiens	-	DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
DEAE-Sepharose column chromatography	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
colorectal cancer cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA (containing 6-O-carboxymethylguanine) + protein L-cysteine	-	Homo sapiens	DNA (without 6-O-carboxymethylguanine) + protein S-carboxymethyl-L-cysteine	-	?
DNA (containing 6-O-methylguanine) + protein L-cysteine	-	Homo sapiens	DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine	-	?

Synonyms

Synonyms	Comment	Organism
MGMT	-	Homo sapiens
O6-methylguanine-DNA methyltransferase	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00000093	-	in 50 mM Tris-HCl pH 8.3, at 37°C	Homo sapiens	DNA (containing 6-O-methylguanine)
0.0000018	-	in 50 mM Tris-HCl pH 8.3, at 37°C	Homo sapiens	DNA (containing 6-O-carboxymethylguanine)

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Release 2023.1 (January 2023)