Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA (containing 6-O-methylguanine) + protein L-cysteine | Homo sapiens | - |
DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine | - |
? | |
DNA (containing O6-chloroethylguanine) + protein L-cysteine | Homo sapiens | - |
DNA (without O6-chloroethylguanine) + protein S-chloroethyl-L-cysteine | - |
? | |
DNA (containing O6-[4-oxo-4-(3-pyridyl)butyl]guanine) + protein L-cysteine | Homo sapiens | - |
DNA (without O6-[4-oxo-4-(3-pyridyl)butyl]guanine) + protein S-4-oxo-4-(3-pyridyl)butyl-L-cysteine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | - |
Homo sapiens | - |
rectum | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA (containing 6-O-methylguanine) + protein L-cysteine | - |
Homo sapiens | DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine | - |
? | |
DNA (containing O6-chloroethylguanine) + protein L-cysteine | - |
Homo sapiens | DNA (without O6-chloroethylguanine) + protein S-chloroethyl-L-cysteine | - |
? | |
DNA (containing O6-[4-oxo-4-(3-pyridyl)butyl]guanine) + protein L-cysteine | - |
Homo sapiens | DNA (without O6-[4-oxo-4-(3-pyridyl)butyl]guanine) + protein S-4-oxo-4-(3-pyridyl)butyl-L-cysteine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MGMT | - |
Homo sapiens |
O6-methylguanine-DNA methyltransferase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme deficiency leads to a tremendously enhanced sensitivity toward alkylation-induced colorectal carcinogenesis | Homo sapiens |
physiological function | the suicide DNA repair protein plays role in the protection against the cytotoxic and mutagenic effects of alkylating agents causing colorectal carcinogenesis | Homo sapiens |