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Literature summary for 2.1.1.63 extracted from

  • Zhong, Y.; Huang, Y.; Huang, Y.; Zhang, T.; Ma, C.; Zhang, S.; Fan, W.; Chen, H.; Qian, J.; Lu, D.
    Effects of O6-methylguanine-DNA methyltransferase (MGMT) polymorphisms on cancer: a meta-analysis (2010), Mutagenesis, 25, 83-95.
    View publication on PubMed
Search for more literature for 2.1.1.63

Protein Variants

Protein Variants Comment Organism
I143V no significant association between the G allele of I143Val and cancer risk is found Homo sapiens
L84F a significant association is found between the T allele of L84F and cancer risk Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine Homo sapiens
-
 DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine
-
 Homo sapiens DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
 ?

Synonyms

Synonyms Comment Organism
AGAT
-
 Homo sapiens
AGT
-
 Homo sapiens
ATASE
-
 Homo sapiens
MGMT
-
 Homo sapiens
O6-methylguanine-DNA methyltransferase
-
 Homo sapiens