Literature summary for 2.1.1.63 extracted from

Kim, J.I.; Suh, J.T.; Choi, K.U.; Kang, H.J.; Shin, D.H.; Lee, I.S.; Moon, T.Y.; Kim, W.T.
Inactivation of O6-methylguanine-DNA methyltransferase in soft tissue sarcomas: association with K-ras mutations (2009), Hum. Pathol., 40, 934-941.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
soft tissue sarcoma cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine	-	Homo sapiens	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?

Synonyms

Synonyms	Comment	Organism
MGMT	-	Homo sapiens
O6-methylguanine-DNA methyltransferase	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	a loss of MGMT expression is noted in 20 cases of 60 total soft tissue sarcomas	down

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Release 2023.1 (January 2023)