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Literature summary for 2.1.1.63 extracted from

  • Nakajima, T.; Yamada, Y.; Shimoda, T.; Matsubara, J.; Kato, K.; Hamaguchi, T.; Shimada, Y.; Okayama, Y.; Oka, T.; Shirao, K.
    Combination of O6-methylguanine-DNA methyltransferase and thymidylate synthase for the prediction of fluoropyrimidine efficacy (2008), Eur. J. Cancer, 44, 400-407.
    View publication on PubMed
Search for more literature for 2.1.1.63

Application

Application Comment Organism
medicine the combination of high thymidylate synthase and low O6-methylguanine-DNA methyltransferase expression is a significant predictor of a poor response to fluoropyrimidine treatment Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine Homo sapiens
-
 DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell
-
 Homo sapiens
-
primary cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine
-
 Homo sapiens DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
 ?

Synonyms

Synonyms Comment Organism
MGMT
-
 Homo sapiens
O6-methylguanine-DNA methyltransferase
-
 Homo sapiens