Literature summary for 2.1.1.63 extracted from

Lai, J.C.; Cheng, Y.W.; Goan, Y.G.; Chang, J.T.; Wu, T.C.; Chen, C.Y.; Lee, H.
Promoter methylation of O(6)-methylguanine-DNA-methyltransferase in lung cancer is regulated by p53 (2008), DNA Repair, 7, 1352-1363.

Search for more literature for 2.1.1.63

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-
NCI-H1299 cell	-	Homo sapiens	-
NCI-H1355 cell	-	Homo sapiens	-
NCI-H23 cell	-	Homo sapiens	-
NCI-H441 cell	-	Homo sapiens	-
NCI-H460 cell	-	Homo sapiens	-
NHBE cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine	-	Homo sapiens	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?

Synonyms

Synonyms	Comment	Organism
MGMT	-	Homo sapiens
O6-methylguanine-DNA-methyltransferase	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	promoter methylation of O6-methylguanine-DNA-methyltransferase in lung cancer is regulated by p53	additional information

General Information

General Information	Comment	Organism
physiological function	MGMT promoter methylation modulated by p53 status can partially promote p53 mutation occurrence in advanced lung tumors	Homo sapiens

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Release 2023.1 (January 2023)