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Literature summary for 2.1.1.63 extracted from

  • Jeuken, J.W.; Cornelissen, S.J.; Vriezen, M.; Dekkers, M.M.; Errami, A.; Sijben, A.; Boots-Sprenger, S.H.; Wesseling, P.
    MS-MLPA: an attractive alternative laboratory assay for robust, reliable, and semiquantitative detection of MGMT promoter hypermethylation in gliomas (2007), Lab. Invest., 87, 1055-1065.
    View publication on PubMed
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Application

Application Comment Organism
diagnostics introduction of the MS-MLPA assay may not only be helpful for predicting response of gliomas to temozolomide, but may also facilitate tailor-made treatment with other chemotherapeutic agents for a variety of tumors Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
temozolomide TMZ Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA (containing 6-O-methylguanine) + [protein]-L-cysteine Homo sapiens
-
 DNA (without 6-O-methylguanine) + [protein]-S-methyl-L-cysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
glioma cell biopsies Homo sapiens
-
glioma cell line
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA (containing 6-O-methylguanine) + [protein]-L-cysteine
-
 Homo sapiens DNA (without 6-O-methylguanine) + [protein]-S-methyl-L-cysteine
-
 ?

Synonyms

Synonyms Comment Organism
AGT
-
 Homo sapiens
MGMT
-
 Homo sapiens
O6-alkylguanine-DNA alkyltransferase
-
 Homo sapiens
O6-methylguanine-DNA methyltransferase
-
 Homo sapiens