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Literature summary for 2.1.1.63 extracted from

  • Shibata, T.; Glynn, N.; McMurry, T.B.; McElhinney, R.S.; Margison, G.P.; Williams, D.M.
    Novel synthesis of O6-alkylguanine containing oligodeoxyribonucleotides as substrates for the human DNA repair protein, O6-methylguanine DNA methyltransferase (MGMT) (2006), Nucleic Acids Res., 34, 1884-1891.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.63

Application

Application Comment Organism
drug development highly effective inactivation of MGMT by an oligodeoxyribonucleotide containing O6-(4-bromothenyl)guanine suggests that such oligodeoxyribonucleotides might have therapeutic applications if problems of delivery can be addressed Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
overexpressed in Escherichia coli strain UC978 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information hydroxyethyl guanine-modified oligodeoxyribonucleotides are not effective inactivators of MGMT Homo sapiens
O6-(4-bromothenyl)guanine most potent inactivator described to date Homo sapiens
O6-benzylguanine
-
 Homo sapiens
O6-methylguanine
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine
-
 Homo sapiens DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
 ?

Synonyms

Synonyms Comment Organism
MGMT
-
 Homo sapiens
O6-methylguanine DNA methyltransferase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000001
-
-
 Homo sapiens O6-(4-bromothenyl)guanine