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Literature summary for 2.1.1.63 extracted from

  • Mattern, J.; Eichhorn, U.; Kaina, B.; Volm, M.
    O6-Methylguanine-DNA methyltransferase activity and sensitivity to cyclophosphamide and cisplatin in human lung tumor xenografts (1998), Int. J. Cancer, 77, 919-922.
    View publication on PubMed

Application

Application Comment Organism
medicine high level of enzyme in tumors and relative resistance to cyclophosphamide in lung cancer indicates that 6-O-methylguanine-DNA methyltransferase may be a predictive factor of resistance to cyclophosphamide Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information high level of enzyme in tumors and relative resistance to cyclophosphamide in lung cancer indicates that 6-O-methylguanine-DNA methyltransferase may be a predictive factor of resistance to cyclophosphamide Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung cancer cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine
-
Homo sapiens DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
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