Literature summary for 2.1.1.63 extracted from

Oh, H.K.; Teo, A.K.C.; Ali, R.B.; Lim, A.; Ayi, T.C.; Yarosh, D.B.; Li, B.F.L.
Conformational change in human DNA repair enzyme O6-methylguanine-DNA methyltransferase upon alkylation of its active site by SN1 (indirect-acting) and SN2 (direct-acting) alkylating agents: breaking a "salt-link"? (1996), Biochemistry, 35, 12259-12266.

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Protein Variants

Protein Variants	Comment	Organism
K107L	mutant is deficient in DNA repair	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
methyl iodide	can directly alkylate the active site of the enzyme, the agent can increase the effectiveness of environmental and endogenously produced alkylating carcinogens in producing the mutagenic 6-O-alkylguanine residue in DNA in vivo	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine	Homo sapiens	the enzyme repairs DNA by transferring alkyl (R)-adducts from 6-O-alkylguanine in DNA to its own cysteine residue at codon 145	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine	the enzyme repairs DNA by transferring alkyl (R)-adducts from 6-O-alkylguanine in DNA to its own cysteine residue at codon 145	Homo sapiens	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?

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Release 2023.1 (January 2023)