Application | Comment | Organism |
---|---|---|
medicine | both melanotic melanoma SK-mel-1 and Ha-Cat cells express COMT activity. In SK-mel-1, COMT activity is reduced nearly 50% both 24 h and 48 h after a high dose UVB. In Ha-Cat cells, COMT activity increases 24 h after a high dose UVB but decreases at 48 h. Tolcapone increases significantly the cytotoxic effect of high dose UVB irradiation only in HaCat. High concentrations of tolcapone reduce melanin levels in melanoma cells parallel to reduced cell numbers | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
tolcapone | tolcapone increases significantly the cytotoxic effect of high dose UVB irradiation in HaCat cells. High concentrations of tolcapone reduce melanin levels in melanoma cells parallel to reduced cell numbers | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HaCaT cell | - |
Homo sapiens | - |
SK-MEL-1 cell | - |
Homo sapiens | - |