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Literature summary for 2.1.1.6 extracted from

  • Yalcin, D.; Bayraktar, O.
    Inhibition of catechol-O-methyltransferase (COMT) by some plant-derived alkaloids and phenolics (2010), J. Mol. Catal. B, 64, 162-166.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
3,5-dinitrocatechol uncompetitive inhibitor Sus scrofa domesticus
Cistus parviflorus leaf extract mixed type inhibition Sus scrofa domesticus
Harmaline
-
Sus scrofa domesticus
harmalol
-
Sus scrofa domesticus
Peganum harmala seed extract mixed type inhibition Sus scrofa domesticus
Vitex agnus-cactus leaf extract mixed type inhibition Sus scrofa domesticus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0035
-
S-adenosyl-L-methionine pH 7.4, 37°C Sus scrofa domesticus
0.0064
-
aesculetin pH 7.4, 37°C Sus scrofa domesticus

Organism

Organism UniProt Comment Textmining
Sus scrofa domesticus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
commercial preparation Sus scrofa domesticus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Sus scrofa domesticus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00107
-
pH 7.4, 37°C Sus scrofa domesticus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
aesculetin + S-adenosyl-L-methionine
-
Sus scrofa domesticus scopoletin + S-adenosyl-L-homocysteine
-
?

Synonyms

Synonyms Comment Organism
catechol-O-methyltransferase
-
Sus scrofa domesticus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000456
-
3,5-dinitrocatechol pH 7.4, 37°C Sus scrofa domesticus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00004418
-
pH 7.4, 37°C Sus scrofa domesticus 3,5-dinitrocatechol
0.00457
-
pH 7.4, 37°C Sus scrofa domesticus Harmaline
0.01319
-
pH 7.4, 37°C Sus scrofa domesticus harmalol