Literature summary for 2.1.1.6 extracted from

Salama, S.A.; Kamel, M.; Awad, M.; Nasser, A.H.; Al-Hendy, A.; Botting, S.; Arrastia, C.
Catecholestrogens induce oxidative stress and malignant transformation in human endometrial glandular cells: protective effect of catechol-O-methyltransferase (2008), Int. J. Cancer, 123, 1246-1254.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
endometrial gland	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
COMT	-	Homo sapiens
MB-COMT	membrane-bound isoform	Homo sapiens
S-COMT	soluble isoform	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	knockdown of COMT expression in endometrial glandular cells results in increased estrogenic milieu and increased estrogen-induced cell proliferation, and increases the propensity of estrogen or catecholestrogens to induce reactive oxygen species, microsatellite instability, and neoplastic transformation of endometrial glandular cells	Homo sapiens
physiological function	COMT gene expression plays a critical role in modulating the hormonal and carcinogenic effects of estrogen and catecholestrogens and, consequently, modifies the risk for estrogen-induced endometrial cancer	Homo sapiens

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Release 2023.1 (January 2023)