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BRENDA support

Literature summary for 2.1.1.6 extracted from

  • Ross, J.R.; Riley, J.; Taegetmeyer, A.B.; Sato, H.; Gretton, S.; du Bois, R.M.; Welsh, K.I.
    Genetic variation and response to morphine in cancer patients: catechol-O-methyltransferase and multidrug resistance-1 gene polymorphisms are associated with central side effects (2008), Cancer, 112, 1390-1403.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information genetic variation in the catechol-O-methyltansferase enzyme is associated independently with morphine-related central side effects in cancer patients, such as drowsiness, confusion, and hallucinations. Single nucleotide polymorphisms in intron 1 are associated significantly with these central side effects, the most significant is at position 24873G Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Synonyms

Synonyms Comment Organism
COMT
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Homo sapiens