Literature summary for 2.1.1.6 extracted from

Papaleo, F.; Crawley, J.N.; Song, J.; Lipska, B.K.; Pickel, J.; Weinberger, D.R.; Chen, J.
Genetic dissection of the role of catechol-O-methyltransferase in cognition and stress reactivity in mice (2008), J. Neurosci., 28, 8709-8723.

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Cloned(Commentary)

Cloned (Comment)	Organism
generation of transgenic mice overexpressing a human COMT-Val polymorphism	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	increased COMT enzyme activity in transgenic mice overexpressing a human COMT-Val polymorphism (Val-tg mice) results in disrupted attentional set-shifting abilities, and impaired working and recognition memory, but blunted stress responses and pain sensitivity. COMT disruption improves working memory, but increased stress responses and pain sensitivity. The COMT gene has a critical role in an apparent evolutionary trade-off between cognitive and affective functions	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P21964	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	increased COMT enzyme activity in transgenic mice overexpressing a human COMT-Val polymorphism (Val-tg mice) results in disrupted attentional set-shifting abilities, and impaired working and recognition memory, but blunted stress responses and pain sensitivity. COMT disruption improves working memory, but increased stress responses and pain sensitivity. The COMT gene has a critical role in an apparent evolutionary trade-off between cognitive and affective functions	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
COMT	-	Homo sapiens

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Release 2023.1 (January 2023)