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Literature summary for 2.1.1.6 extracted from
- Effects of a catechol-O-methyltransferase inhibitor on catechol estrogen-induced cellular transformation, chromosome aberrations and apoptosis in Syrian hamster embryo cells (2007), Int. J. Cancer, 120, 1627-1633.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | COMT activity has an influence on cell transforming activity and its related genetic effects of catechol estrogens imply that an individual activity of COMT may be one of the etiological factors in endogenous estrogen-induced carcinogenesis | Mesocricetus auratus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mesocricetus auratus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | - |
Mesocricetus auratus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-hydroxyestrone + S-adenosyl-L-methionine | the production of 2-methoxyestrone in cultures treated with 2-hydroxyestrone is approximately 2fold that of 4-methoxyestrone in cultures treated with 4-hydroxyestrone | Mesocricetus auratus | S-adenosyl-L-homocysteine + ? | - |
? |  |
| 4-hydroxyestrone + S-adenosyl-L-methionine | - |
Mesocricetus auratus | S-adenosyl-L-homocysteine + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| COMT | - |
Mesocricetus auratus |
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Release 2023.1 (January 2023)
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