Literature summary for 2.1.1.6 extracted from

Halleland, H.; Lundervold, A.J.; Halmy, A.; Haavik, J.; Johansson, S.
Association between catechol O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in adults (2009), Am. J. Med. Genet. B Neuropsychiatr. Genet., 150B, 403-410.

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Application

Application	Comment	Organism
medicine	single nucleotide polymorphisms rs6269, rs4633, rs4818, and rs4680, tagging the common putative functional COMT haplotypes, are genotyped in 435 adult subjects with a clinical diagnosis of ADHD and 383 controls and analyzed for association with attention-deficit/hyperactivity disorder and the hyperactivity/impulsivity and in attention dimensions from the Adult ADHD Self-Report Scale. Haplotype analysis reveales that the rs6269 risk allele tags the suggested high COMT-activity haplotype, which is associated with the highest hyperactivity/impulsivity score	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

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Release 2023.1 (January 2023)