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Literature summary for 2.1.1.59 extracted from

  • Durban, E.; Kim, S.; Jun, G.J.; Paik, W.K.
    Cytochrome c-specific protein-lysine methyltransferase from Neurospora crassa: kinetic mechanism (1983), Korean J. Biochem., 15, 19-24.
No PubMed abstract available
Search for more literature for 2.1.1.59

Inhibitors

Inhibitors Comment Organism Structure
S-adenosyl-L-homocysteine competitive versus S-adenosyl-L-methionine Neurospora crassa
S-adenosyl-L-methionine
-
 Neurospora crassa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.7
-
 [cytochrome c]-L-lysine
-
 Neurospora crassa
19
-
 S-adenosyl-L-methionine
-
 Neurospora crassa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + cytochrome c L-lysine Neurospora crassa
-
 S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
 ?

Organism

Organism UniProt Comment Textmining
Neurospora crassa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Neurospora crassa

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + [cytochrome c]-L-lysine = S-adenosyl-L-homocysteine + [cytochrome c]-N6-methyl-L-lysine hybrid ping-pong mechanism Neurospora crassa
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + cytochrome c L-lysine
-
 Neurospora crassa S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
 ?
S-adenosyl-L-methionine + cytochrome c L-lysine horse heart cytochrome c-72 Neurospora crassa S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine
-
 ?
S-adenosyl-L-methionine + [cytochrome c]-L-lysine
-
 Neurospora crassa S-adenosyl-L-homocysteine + [cytochrome c]-N6-methyl-L-lysine
-
 r

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.002
-
 S-adenosyl-L-methionine
-
 Neurospora crassa