Literature summary for 2.1.1.57 extracted from

Hu, G.; Tsai, A.L.; Quiocho, F.A.
Insertion of an N7-methylguanine mRNA cap between two coplanar aromatic residues of a cap-binding protein is fast and selective for a positively charged cap (2003), J. Biol. Chem., 278, 51515-51520.

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Protein Variants

Protein Variants	Comment	Organism
F180W	no apparent defects in catalytic activity	Vaccinia virus

Organism

Organism	UniProt	Comment	Textmining
Vaccinia virus	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
S-adenosyl-L-methionine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]	simple one-step reaction mechanism, only the positively charged keto tautomer of the cap is recognized and bound. Binding is achieved almost entirely by the interactions of m7guanosine with two aromatic residues in a cation-pi sandwich	Vaccinia virus	a

Synonyms

Synonyms	Comment	Organism
VP39	-	Vaccinia virus

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Release 2023.1 (January 2023)