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Literature summary for 2.1.1.56 extracted from

  • Milani, M.; Mastrangelo, E.; Bollati, M.; Selisko, B.; Decroly, E.; Bouvet, M.; Canard, B.; Bolognesi, M.
    Flaviviral methyltransferase/RNA interaction: structural basis for enzyme inhibition (2009), Antiviral Res., 83, 28-34.
    View publication on PubMed
Search for more literature for 2.1.1.56

Inhibitors

Inhibitors Comment Organism Structure
aurintricarboxylic acid strong inhibition at 0.025 mM Dengue virus
aurintricarboxylic acid strong inhibition at 0.025 mM Wesselsbron virus
additional information nilutamide and PPDNS do not display efficient inhibition at 0.025 and 0.125 mM Dengue virus
additional information nilutamide and PPDNS do not display efficient inhibition at 0.025 and 0.125 mM Wesselsbron virus

Organism

Organism UniProt Comment Textmining
Dengue virus
-
-
-
Wesselsbron virus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Dengue virus
-
 Wesselsbron virus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + G(5')pppR-RNA
-
 Dengue virus S-adenosyl-L-homocysteine + m7G(5')pppR-RNA
-
 ?
S-adenosyl-L-methionine + G(5')pppR-RNA
-
 Wesselsbron virus S-adenosyl-L-homocysteine + m7G(5')pppR-RNA
-
 ?

Synonyms

Synonyms Comment Organism
guanine-N7 methyltransferase
-
 Dengue virus
guanine-N7 methyltransferase
-
 Wesselsbron virus
N7 methyltransferase
-
 Dengue virus
N7 methyltransferase
-
 Wesselsbron virus
N7 MTase
-
 Dengue virus
N7 MTase
-
 Wesselsbron virus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0023
-
 in 50 mM Tris, pH 7.0, 50 mM NaCl, 2 mM dithiothreitol, at 22°C Dengue virus aurintricarboxylic acid
0.0042
-
 in 50 mM Tris, pH 7.0, 50 mM NaCl, 2 mM dithiothreitol, at 22°C Wesselsbron virus aurintricarboxylic acid