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Literature summary for 2.1.1.56 extracted from

  • Martin, S.A.; Moss, B.
    Modification of RNA by mRNA guanylyltransferase and mRNA (guanine-7-)methyltransferase from vaccinia virions (1975), J. Biol. Chem., 250, 9330-9335.
    View publication on PubMed
Search for more literature for 2.1.1.56

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ strong Vaccinia virus
Cu2+ strong Vaccinia virus
Mg2+ weak Vaccinia virus
Mn2+ weak Vaccinia virus
S-adenosyl-L-homocysteine product inhibition, competitive Vaccinia virus
Zn2+ strong Vaccinia virus

Localization

Localization Comment Organism GeneOntology No. Textmining
viral nucleocapsid
-
 Vaccinia virus 19013
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information no requirement for divalent cations Vaccinia virus

Organism

Organism UniProt Comment Textmining
Vaccinia virus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no methylation of internal or conventional 5'-terminal guanosine residues Vaccinia virus ?
-
 ?
S-adenosyl-L-methionine + G(5')pppR-RNA transfers methyl group from S-adenosyl-L-methionine specifically to position 7 of terminal guanosine Vaccinia virus S-adenosyl-L-homocysteine + m7G(5')pppR-RNA R may be guanosine or adenosine, mRNA containing an N7-methylguanine cap ?
S-adenosyl-L-methionine + G(5')pppR-RNA specific for mRNAs with 5'-terminal sequence G(5')pppA- and G(5')pppG- Vaccinia virus S-adenosyl-L-homocysteine + m7G(5')pppR-RNA R may be guanosine or adenosine, mRNA containing an N7-methylguanine cap ?
S-adenosyl-L-methionine + pp(A)n
-
 Vaccinia virus ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Vaccinia virus

Cofactor

Cofactor Comment Organism Structure
additional information no requirement of GTP Vaccinia virus