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Literature summary for 2.1.1.5 extracted from
- Effects of hyperhomocysteinemia and betaine-homocysteine S-methyltransferase inhibition on hepatocyte metabolites and the proteome (2013), Biochim. Biophys. Acta, 1834, 1596-1606.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | treatment of hepatocytes with homocysteine to follow the impact of hyperhomocysteinemia and concomittant inhibition of betaine-homocysteine S-methyltransferase BHMT. Inhibition and 0.1 mM homocysteine treatment induce only moderate changes in the hepatocyte proteome and secretome, while the changes induced by 2 mM homocysteine treatment are extensive: phosphatidylethanolamine carboxykinase and ornithine aminotransferase are up-regulated about twofold indicating an intervention into metabolism. Cellular proliferation is suspended, secretome composition is changed and signs of apoptosis are discernible. Fibrinogen gamma dimers can be detected and maturation of apolipoprotein A1 fails | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q93088 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hepatocyte | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BHMT | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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