Literature summary for 2.1.1.5 extracted from

Awad, W.M.; Whitney, P.L.; Skiba, W.E.; Mangum, J.H.; Wells, M.S.
Evidence for direct methyl transfer in betaine: homocysteine S-methyl-transferase (1983), J. Biol. Chem., 258, 12790-12792.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Butyrate	-	Homo sapiens
additional information	no inhibition by sarcosine; not inhibitory: S-(gamma-carboxypropyl)-DL-homocysteine, S-(beta-carboxyethyl)-DL-homocysteine	Homo sapiens
S-(delta-Carboxybutyl)-DL-homocysteine	strong	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
betaine + L-homocysteine = dimethylglycine + L-methionine	mechanism	Homo sapiens	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N,N,N-trimethylglycine + L-homocysteine	i.e. betaine, methyl transfer directly from one substrate to the other	Homo sapiens	N,N-dimethylglycine + L-methionine	-	?

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Release 2023.1 (January 2023)