Literature summary for 2.1.1.45 extracted from

Antosiewicz, A.; Jarmula, A.; Przybylska, D.; Mosieniak, G.; Szczepanowska, J.; Kowalkowska, A.; Rode, W.; Ciesla, J.
Human dihydrofolate reductase and thymidylate synthase form a complex in vitro and co-localize in normal and cancer cells (2017), J. Biomol. Struct. Dyn., 35, 1474-1490 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-
nucleus	-	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P04818	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	-	Homo sapiens	-
HCT-116 cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	human thymidylate synthase and dihydrofolate reductase form a strong complex in vitro and colocalize in human normal and colon cancer cell cytoplasm and nucleus. Treatment of cancer cells with methotrexate or 5-fluorouracil does not affect the distribution of either enzyme within the cells. 5-fluorouracil, but not methotrexate, lowers the presence of dihydrofolate reductase-thymidylate synthase complex in the nucleus by 2.5fold	Homo sapiens

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Release 2023.1 (January 2023)