Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.45 extracted from

  • Giovannetti, E.; Backus, H.H.; Wouters, D.; Peters, G.J.
    Functional inactivity and mutations of p53 differentially affect sensitivity to 5-fluorouracil and antifolate inhibitors of thymidylate synthase (TS) by altering TS levels in colorectal cancer cells (2008), Nucleosides Nucleotides Nucleic Acids, 27, 740-745.
    View publication on PubMed
Search for more literature for 2.1.1.45

Inhibitors

Inhibitors Comment Organism Structure
5-fluorouracil transfection with p53 induces resistance to 5-fluorouracil Homo sapiens
GW1843U89
-
 Homo sapiens
nolatrexed transfection with p53 induces resistance to nolatrexed Homo sapiens
pemetrexed transfection with p53 induces resistance to pemetrexed Homo sapiens
raltitrexed transfection with p53 induces resistance to raltitrexed Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP Homo sapiens thymidylate synthase is a key enzyme in the de novo synthesis of dTMP 7,8-dihydrofolate + dTMP
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell
-
 Homo sapiens
-
Lovo-175X2 cell colorectal cancer cell, mutated subline of Lovo-92 cell Homo sapiens
-
Lovo-273X17 cell colorectal cancer cell, mutated subline of Lovo-92 cell Homo sapiens
-
Lovo-92 cell wildtype p53 colorectal cancer cell Homo sapiens
-
Lovo-li cell colorectal cancer cell harboring a functionally inactive p53 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP
-
 Homo sapiens 7,8-dihydrofolate + dTMP
-
 ?
5,10-methylenetetrahydrofolate + dUMP thymidylate synthase is a key enzyme in the de novo synthesis of dTMP Homo sapiens 7,8-dihydrofolate + dTMP
-
 ?