Application | Comment | Organism |
---|---|---|
medicine | the use of the TS inhibitor RTX in the treatment of colorectal cancer has been approved in Europe, Canada, Australia and Japan | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
raltitrexed | RTX, a folate analog that is a specific inhibitor of TS; treatment can stimulate accurate recombination events in human cells. Gene conversions not associated with crossovers are specifically enhanced severalfold. Recombination events provoked by a double-strand break are not impacted by treatment with raltitrexed, nor is error-prone double-strand break repair via nonhomologous end-joining | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + dUMP | Homo sapiens | during TS inhibition, TMP levels decrease with a subsequent increase in dUTP | 7,8-dihydrofolate + dTMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
GM00637 cell | normal human fibroblast cell line immortalized by SV40 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + dUMP | - |
Homo sapiens | 7,8-dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | during TS inhibition, TMP levels decrease with a subsequent increase in dUTP | Homo sapiens | 7,8-dihydrofolate + dTMP | - |
? |