Literature summary for 2.1.1.45 extracted from

Anderson, A.C.; Perry, K.M.; Freymann, D.M.; Stroud, R.M.
The crystal structure of thymidylate synthase from Pneumocystis carinii reveals a fungal insert important for drug design (2000), J. Mol. Biol., 297, 645-657.

Search for more literature for 2.1.1.45

Application

Application	Comment	Organism
medicine	important drug target, fungus causes opportunistic pneumonia infections in immune-compromised patients and is among the leading causes of death of AIDS patients, inhibitors selective for fungal TS over human TS will be greatly beneficial in combating this disease	Pneumocystis carinii

Crystallization (Commentary)

Crystallization (Comment)	Organism
-	Pneumocystis carinii

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
5,10-methylenetetrahydrofolate + dUMP	Pneumocystis carinii	biosynthesis of thymidylic acid, only de novo source of thymidine, crucial for DNA replication in every organism	dihydrofolate + dTMP	-	?

Organism

Organism	UniProt	Comment	Textmining
Pneumocystis carinii	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5,10-methylenetetrahydrofolate + dUMP	-	Pneumocystis carinii	dihydrofolate + dTMP	-	r
5,10-methylenetetrahydrofolate + dUMP	biosynthesis of thymidylic acid, only de novo source of thymidine, crucial for DNA replication in every organism	Pneumocystis carinii	dihydrofolate + dTMP	-	?

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Release 2023.1 (January 2023)