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Literature summary for 2.1.1.45 extracted from

  • Schiffer, C.A.; Clifton, I.J.; Davisson, V.J.; Santi, D.V.; Stroud, R.M.
    Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site (1995), Biochemistry, 34, 16279-16287.
    View publication on PubMed

Application

Application Comment Organism
medicine enzyme is believed to be the major site of the cytotoxic action of the cancer chemotherapeutic drug 5-fluorouracil, development of inhibitors as clinical useful drugs Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP Homo sapiens
-
dihydrofolate + dTMP
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP
-
Homo sapiens dihydrofolate + dTMP
-
?
5,10-methylenetetrahydrofolate + dUMP
-
Homo sapiens dihydrofolate + dTMP
-
r