Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,4-diamino pteridine | - |
Streptococcus pneumoniae | |
2,4-diamino quinazoline antifolate | - |
Streptococcus pneumoniae | |
2-amino-4-hydroxyquinazoline | - |
Streptococcus pneumoniae | |
aminopterin | - |
Streptococcus pneumoniae | |
deaza-aminopterin | - |
Streptococcus pneumoniae | |
methasquin | - |
Streptococcus pneumoniae | |
methopterin | - |
Escherichia coli | |
methopterin | - |
Streptococcus pneumoniae | |
quinaspar | - |
Streptococcus pneumoniae | |
SK 28,757 | - |
Streptococcus pneumoniae | |
SK 28,758 | - |
Streptococcus pneumoniae | |
SK 28,815 | - |
Streptococcus pneumoniae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0308 | - |
2'-deoxyuridylate | - |
Streptococcus pneumoniae | |
0.266 | - |
5,10-methylenetetrahydrofolate | - |
Streptococcus pneumoniae |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Escherichia coli | |
Mg2+ | - |
Lacticaseibacillus casei | |
Mg2+ | requirement depending upon the buffer | Streptococcus pneumoniae |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
34000 | 38000 | gel filtration, sucrose density-gradient centrifugation | Streptococcus pneumoniae |
35000 | - |
2 * 35000, SDS-PAGE | Lacticaseibacillus casei |
58000 | - |
- |
Gallus gallus |
70000 | - |
- |
Escherichia coli |
70000 | - |
- |
Streptococcus pneumoniae |
70000 | - |
- |
Lacticaseibacillus casei |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + dUMP | Gallus gallus | - |
dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | Escherichia coli | - |
dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | Streptococcus pneumoniae | - |
dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | Lacticaseibacillus casei | - |
dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | Enterococcus faecium | - |
dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | Escherichia coli B / ATCC 11303 | - |
dihydrofolate + dTMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Enterococcus faecium | - |
var. durans | - |
Escherichia coli | - |
- |
- |
Escherichia coli B / ATCC 11303 | - |
- |
- |
Gallus gallus | - |
- |
- |
Lacticaseibacillus casei | - |
- |
- |
Streptococcus pneumoniae | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Gallus gallus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.002 | - |
- |
Streptococcus pneumoniae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + dUMP | - |
Gallus gallus | dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | - |
Gallus gallus | dihydrofolate + dTMP | - |
r | |
5,10-methylenetetrahydrofolate + dUMP | - |
Escherichia coli | dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | - |
Escherichia coli | dihydrofolate + dTMP | - |
r | |
5,10-methylenetetrahydrofolate + dUMP | - |
Streptococcus pneumoniae | dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | - |
Streptococcus pneumoniae | dihydrofolate + dTMP | - |
r | |
5,10-methylenetetrahydrofolate + dUMP | - |
Lacticaseibacillus casei | dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | - |
Lacticaseibacillus casei | dihydrofolate + dTMP | - |
r | |
5,10-methylenetetrahydrofolate + dUMP | - |
Enterococcus faecium | dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | - |
Enterococcus faecium | dihydrofolate + dTMP | - |
r | |
5,10-methylenetetrahydrofolate + dUMP | - |
Escherichia coli B / ATCC 11303 | dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | - |
Escherichia coli B / ATCC 11303 | dihydrofolate + dTMP | - |
r | |
additional information | uridylate, cytidylate and deoxycytidylate are not substrates | Streptococcus pneumoniae | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Escherichia coli |
dimer | 2 * 35000, SDS-PAGE | Lacticaseibacillus casei |
dimer | 2 * 34000-38000 | Streptococcus pneumoniae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | 7.7 | - |
Streptococcus pneumoniae |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5 | 8 | - |
Streptococcus pneumoniae |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0013 | - |
SK 28,757 | - |
Streptococcus pneumoniae | |
0.0013 | - |
2,4-diamino quinazoline | - |
Streptococcus pneumoniae | |
0.0015 | - |
SK 28,758 | - |
Streptococcus pneumoniae | |
0.0029 | - |
methasquin | - |
Streptococcus pneumoniae | |
0.0029 | - |
SK 28,815 | - |
Streptococcus pneumoniae | |
0.003 | - |
2,4-diamino quinazoline antifolate | - |
Streptococcus pneumoniae | |
0.0044 | - |
quinaspar | - |
Streptococcus pneumoniae | |
0.0075 | - |
deaza-aminopterin | - |
Streptococcus pneumoniae | |
0.0284 | - |
methopterin | - |
Streptococcus pneumoniae | |
0.03 | - |
2,4-diamino pteridine | - |
Streptococcus pneumoniae | |
0.0347 | - |
aminopterin | - |
Streptococcus pneumoniae |