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Literature summary for 2.1.1.45 extracted from

  • Kisliuk, R.L.; Gaumont, Y.
    Polyglutamyl derivatives of folate as substrates and inhibitors of thymidylate synthetase (1974), J. Biol. Chem., 249, 4100-4103.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(6R)-tetrahydropteroylglutamate
-
Lacticaseibacillus casei
dihydropteroylhexaglutamate
-
Lacticaseibacillus casei
dihydropteroyltriglutamate
-
Lacticaseibacillus casei
pteroylhexaglutamate
-
Lacticaseibacillus casei
pteroylpolyglutamate
-
Lacticaseibacillus casei

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.025
-
(l)-tetrahydropteroyltriglutamate
-
Lacticaseibacillus casei
0.061
-
(6S)-tetrahydropteroylglutamate
-
Lacticaseibacillus casei
0.077
-
tetrahydropteroylglutamate
-
Lacticaseibacillus casei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP Lacticaseibacillus casei
-
dihydrofolate + dTMP
-
?

Organism

Organism UniProt Comment Textmining
Lacticaseibacillus casei
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6S)-methylenetetrahydropteroylhexaglutamate + 2'-deoxyuridylate
-
Lacticaseibacillus casei 7,8-dihydropteroylhexaglutamate + thymidine phosphate
-
r
(6S)-tetrahydropteroylglutamate + 2-deoxyuridylate
-
Lacticaseibacillus casei 7,8-dihydropteroylglutamate + thymidine phosphate
-
r
(6S)-tetrahydropteroyltriglutamate + 2'-deoxyuridylate
-
Lacticaseibacillus casei 7,8-dihydropteroyltriglutamate + thymidine phosphate
-
r
5,10-methylenetetrahydrofolate + dUMP
-
Lacticaseibacillus casei dihydrofolate + dTMP
-
?
5,10-methylenetetrahydrofolate + dUMP
-
Lacticaseibacillus casei dihydrofolate + dTMP
-
r