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Literature summary for 2.1.1.45 extracted from
- Properties and inhibition of thymidylate synthetase in Drosophila melanogaster (1974), J. Insect Physiol., 20, 1389-1401.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-fluorouracil | - |
Drosophila melanogaster |  |
| fluorodeoxyuridine monophosphate | - |
Drosophila melanogaster | |
| methotrexate | - |
Drosophila melanogaster | |
| trifluoromethyldeoxyuridine 5'-monophosphate | - |
Drosophila melanogaster | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate + dUMP | Drosophila melanogaster | - |
dihydrofolate + dTMP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate + dUMP | - |
Drosophila melanogaster | dihydrofolate + dTMP | - |
? | |
| 5,10-methylenetetrahydrofolate + dUMP | - |
Drosophila melanogaster | dihydrofolate + dTMP | - |
r | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8 | - |
Drosophila melanogaster |
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