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Literature summary for 2.1.1.41 extracted from

  • Kaneshiro, E.S.; Rosenfeld, J.A.; Basselin-Eiweida, M.; Stringer, J.R.; Keely, S.P.; Smulian, A.G.; Giner, J.L.
    The Pneumocystis carinii drug target s-adenosyl-L-methionine:Sterol C-24 methyl transferase has a unique substrate preference (2002), Mol. Microbiol., 44, 989-999.
    View publication on PubMed

Application

Application Comment Organism
medicine target for drug development against pneumonitis caused by this pathogen based on its unique substrate preference for lanosterol and 24-methylenelanosterol Pneumocystis carinii

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli, His-tagged protein Pneumocystis carinii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0106
-
lanosterol recombinant enzyme Pneumocystis carinii
0.019
-
24-methylenelanosterol recombinant enzyme Pneumocystis carinii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
zymosterol + S-adenosyl-L-methionine Pneumocystis carinii
-
fecosterol + S-adenosyl-L-homocysteine
-
?

Organism

Organism UniProt Comment Textmining
Pneumocystis carinii
-
-
-

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol substrate binding, amino acid sequence Pneumocystis carinii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
24-methylenelanosterol + S-adenosyl-L-methionine preferred substrate Pneumocystis carinii pneumocysterol + S-adenosyl-L-homocysteine
-
?
lanosterol + S-adenosyl-L-methionine preferred substrate Pneumocystis carinii 24-methylene-24,25-dihydrolanosterol + S-adenosyl-L-homocysteine
-
?
zymosterol + S-adenosyl-L-methionine
-
Pneumocystis carinii fecosterol + S-adenosyl-L-homocysteine
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
recombinant enzyme Pneumocystis carinii

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
22 45 recombinant enzyme Pneumocystis carinii

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
recombinant enzyme Pneumocystis carinii

pH Range

pH Minimum pH Maximum Comment Organism
5.5 9 recombinant enzyme Pneumocystis carinii