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Literature summary for 2.1.1.41 extracted from
- Mechanism and structural requirements for transformation of substrates by the (S)-adenosyl-L-methionine:DELTA24(25)-sterol methyl transferase from Saccharomyces cerevisiae (1996), Biochim. Biophys. Acta, 1299, 313-324.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (24,S),25-epiminozymosterol | - |
Saccharomyces cerevisiae |  |
| (24R,S),25-epiminolanosterol | - |
Saccharomyces cerevisiae | |
| (24R,S),25-epiminozymosterol | - |
Saccharomyces cerevisiae | |
| 25-azacholestane | - |
Saccharomyces cerevisiae | |
| 25-Azacholesterol | - |
Saccharomyces cerevisiae | |
| 25-Azacholesterol hydrochloride | - |
Saccharomyces cerevisiae | |
| 25-azalanosterol | - |
Saccharomyces cerevisiae | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | overview | Saccharomyces cerevisiae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| zymosterol + S-adenosyl-L-methionine | Saccharomyces cerevisiae | - |
fecosterol + S-adenosyl-L-homocysteine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
mutant strain GL7 | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol | mechanism | Saccharomyces cerevisiae | |
| S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol | kinetic and inhibition mechanism | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | overview about a large number of sterol substrates of various origin, substrate specificity analysis, structures: overview | Saccharomyces cerevisiae | ? | - |
? | |
| zymosterol + S-adenosyl-L-methionine | - |
Saccharomyces cerevisiae | fecosterol + S-adenosyl-L-homocysteine | - |
? | |
| zymosterol + S-adenosyl-L-methionine | regio- and stereospecific for substrates | Saccharomyces cerevisiae | fecosterol + S-adenosyl-L-homocysteine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| (S)-adenosyl-L-methionine:DELTA24(25)-sterol methyl transferase | - |
Saccharomyces cerevisiae |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00001 | - |
(24R,S),25-epiminolanosterol | - |
Saccharomyces cerevisiae | |
| 0.00001 | - |
(24,S),25-epiminozymosterol | - |
Saccharomyces cerevisiae | |
| 0.000015 | - |
25-Azacholesterol hydrochloride | - |
Saccharomyces cerevisiae | |
| 0.000045 | - |
25-azalanosterol | - |
Saccharomyces cerevisiae | |
| 0.000048 | - |
25-azacholestane | - |
Saccharomyces cerevisiae | |
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