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Literature summary for 2.1.1.4 extracted from

  • Azam, S.; Saroosh, A.; Zaman, N.; Raza, S.
    Role of N-acetylserotonin O-methyltransferase in bipolar disorders and its dynamics (2013), J. Mol. Liq., 182, 25-31.
No PubMed abstract available
Search for more literature for 2.1.1.4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme also catalyzes the conversion of 5-hydroxyindoleacetate to 5-methoxyindoleacetate ?
-
 ?
S-adenosyl-L-methionine + N-acetylserotonin Homo sapiens
-
 S-adenosyl-L-homocysteine + melatonin
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 the ASMT gene is spliced in an alternative way to form at least three possible isoforms
-

Source Tissue

Source Tissue Comment Organism Textmining
pineal gland
-
 Homo sapiens
-
retina
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme also catalyzes the conversion of 5-hydroxyindoleacetate to 5-methoxyindoleacetate Homo sapiens ?
-
 ?
S-adenosyl-L-methionine + N-acetylserotonin
-
 Homo sapiens S-adenosyl-L-homocysteine + melatonin
-
 ?

Synonyms

Synonyms Comment Organism
ASMT
-
 Homo sapiens
hydroxyindole-O-methyltransferase
-
 Homo sapiens
N-acetylserotonin O-methyltransferase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism all three isozymes are involved in the biosynthesis of melatonin. the enzyme is involved in a general tryptophan metabolism pathway where it catalyzes the final reaction in the production of melatonin, converting normelatonin to melatonin (a neurohormone). The conversion of 5-hydroxyindoleacetate to 5-methoxyindoleacetate in the same pathway is also catalyzed by this enzyme. In general tryptophan metabolism pathway, tryptophan functions as a biochemical precursor for serotonin Homo sapiens
additional information structural homology molecular modeling and model evaluation, molecular dynamics simulation, overview. Active site determination and modeling of ligand binding by the enzyme Homo sapiens