Crystallization (Comment) | Organism |
---|---|
structure-based model of the M.HhaI-DNA-cofactor complex. Residues Gln82, Tyr254 and Asn304 are in close proximity and thus might sterically interfere with the extended transferable side chains | Haemophilus parahaemolyticus |
Protein Variants | Comment | Organism |
---|---|---|
N304A | 4fold improved activity with S-adenosyl-L-methionine analog containing a S-butynyl group, 5fold improved actitivity with S-adenosyl-L-methionine analog containing a S-pentynyl group | Haemophilus parahaemolyticus |
Q82A | 4fold improved activity with S-adenosyl-L-methionine analog containing a S-butynyl group, 16fold decrease in activity with S-adenosyl-L-methionine | Haemophilus parahaemolyticus |
Q82A/N304A | no further improvement of activity compared to single mutants | Haemophilus parahaemolyticus |
Q82A/Y254S/N304A | significantly improved actitivity with S-adenosyl-L-methionine analogs containing a S-butynyl, a S-pentynyl or a S-6-(4-aminobutanamido)hex-2-yn-1-yl group | Haemophilus parahaemolyticus |
Y254S | significantly improved actitivity with S-adenosyl-L-methionine analogs containing a S-butynyl or a S-pentynyl group | Haemophilus parahaemolyticus |
Y254S/N304A | significantly improved actitivity with S-adenosyl-L-methionine analogs containing a S-butynyl, a S-pentynyl or a S-6-(4-aminobutanamido)hex-2-yn-1-yl group | Haemophilus parahaemolyticus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Haemophilus parahaemolyticus | P05102 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
hhaIM | - |
Haemophilus parahaemolyticus |
M.HhaI | - |
Haemophilus parahaemolyticus |