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Literature summary for 2.1.1.37 extracted from

  • Borowczyk, E.; Mohan, K.N.; DAiuto, L.; Cirio, M.C.; Chaillet, J.R.
    Identification of a region of the DNMT1 methyltransferase that regulates the maintenance of genomic imprints (2009), Proc. Natl. Acad. Sci. USA, 106, 20806-20811.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
DNMT1, DNA and amino acid sequence determination and analysis, expression of wild-type and mutants in Escherichia coli Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of Dnmt1 mutants, two alleles of the endogenous Dnmt1 locus of R1 embryonic stem cells are sequentially modified using two similar targeting vectors to generate the DOX-OFF Dnmt1tet/tet cell line. The isolated 5' portion of the mouse Dnmt1 gene is used for targeted mutagenesis. Transient absence of DNMT1 expression leads to loss of imprinted methylation. In an embryonic stem cell line endogenous DNMT1s expression is extinguished by the addition of doxycycline, phenotypes, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA + S-adenosyl-L-methionine Mus musculus DNMT1 participates in epigenetic reprogramming through its ability to distinguish different categories of methylated sequences. Genomic imprinting is a mammalian epigenetic process that distinguishes maternal and paternal alleles to ensure parent-specific, monoallelic expression of imprinted genes. Preimplantation DNMT1-dependent maintenance mechanism specifically targets DMD sequences, e.g. of IAP, alpha-actin, Snurf/Snrpn, H19, Gnas, and Gtl2 DMD, overview DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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Organism

Organism UniProt Comment Textmining
Mus musculus
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DNMT1
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Source Tissue

Source Tissue Comment Organism Textmining
embryonic stem cell
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Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA + S-adenosyl-L-methionine
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Mus musculus DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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?
DNA + S-adenosyl-L-methionine DNMT1 participates in epigenetic reprogramming through its ability to distinguish different categories of methylated sequences. Genomic imprinting is a mammalian epigenetic process that distinguishes maternal and paternal alleles to ensure parent-specific, monoallelic expression of imprinted genes. Preimplantation DNMT1-dependent maintenance mechanism specifically targets DMD sequences, e.g. of IAP, alpha-actin, Snurf/Snrpn, H19, Gnas, and Gtl2 DMD, overview Mus musculus DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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?

Synonyms

Synonyms Comment Organism
DNMT1 methyltransferase
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Mus musculus

General Information

General Information Comment Organism
physiological function DNMT1 cytosine methyltransferase governs maintenance methylation in mammals, rearrangements of non-DMD, but not DMD methylation in preimplantation embryos Mus musculus