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Literature summary for 2.1.1.37 extracted from

  • Ooi, S.K.; Bestor, T.H.
    The colorful history of active DNA demethylation (2008), Cell, 133, 1145-1148.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information even modest increases or decreases in levels of m5C cause severe abnormalities or death in mutant mice Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Mus musculus 5634
-
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA + S-adenosyl-L-methionine Mus musculus both DNMT3A and DNMT3B are involved in de novo DNA methylation. 5'-Cytosine methylation is a common epigenetic modification in eukaryotic genomes DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
?
DNA + S-adenosyl-L-methionine Homo sapiens both DNMT3A and DNMT3B are involved in de novo DNA methylation. 5'-Cytosine methylation is a common epigenetic modification in eukaryotic genomes DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
?
additional information Homo sapiens upon activation of ER-target gene expression, CpG dinucleotides of promoters undergo cyclical demethylation and remethylation with a cycle time of roughly 2 h, cyclical recruitment of DNMT3A and DNMT3B DNA methyltransferases to the promoter regions of estrogen receptoralpha target genes. In cancer cells, DNMT3A and DNMT3B might posses deaminase activity and be involved in a dynamic demethylation-methylation pathway that operates during gene transcription, overview ?
-
?
additional information Mus musculus upon activation of ER? target gene expression, CpG dinucleotides of promoters undergo cyclical demethylation and remethylation with a cycle time of roughly 2 h, cyclical recruitment of DNMT3A and DNMT3B DNA methyltransferases to the promoter regions of estrogen receptoralpha target genes. In cancer cells, DNMT3A and DNMT3B might posses deaminase activity and be involved in a dynamic demethylation-methylation pathway that operates during gene transcription, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythroleukemia cell
-
Mus musculus
-
HeLa cell
-
Homo sapiens
-
RKO cell a human colorectal carcinoma cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA + S-adenosyl-L-methionine
-
Mus musculus DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
?
DNA + S-adenosyl-L-methionine
-
Homo sapiens DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
?
DNA + S-adenosyl-L-methionine both DNMT3A and DNMT3B are involved in de novo DNA methylation. 5'-Cytosine methylation is a common epigenetic modification in eukaryotic genomes Mus musculus DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
?
DNA + S-adenosyl-L-methionine both DNMT3A and DNMT3B are involved in de novo DNA methylation. 5'-Cytosine methylation is a common epigenetic modification in eukaryotic genomes Homo sapiens DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
?
additional information upon activation of ER-target gene expression, CpG dinucleotides of promoters undergo cyclical demethylation and remethylation with a cycle time of roughly 2 h, cyclical recruitment of DNMT3A and DNMT3B DNA methyltransferases to the promoter regions of estrogen receptoralpha target genes. In cancer cells, DNMT3A and DNMT3B might posses deaminase activity and be involved in a dynamic demethylation-methylation pathway that operates during gene transcription, overview Homo sapiens ?
-
?
additional information upon activation of ER? target gene expression, CpG dinucleotides of promoters undergo cyclical demethylation and remethylation with a cycle time of roughly 2 h, cyclical recruitment of DNMT3A and DNMT3B DNA methyltransferases to the promoter regions of estrogen receptoralpha target genes. In cancer cells, DNMT3A and DNMT3B might posses deaminase activity and be involved in a dynamic demethylation-methylation pathway that operates during gene transcription, overview Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
Dnmt3a
-
Mus musculus
Dnmt3a
-
Homo sapiens
DNMT3B
-
Mus musculus
DNMT3B
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
Mus musculus
S-adenosyl-L-methionine
-
Homo sapiens

General Information

General Information Comment Organism
metabolism both DNMT3A and DNMT3B are involved in de novo DNA methylation Mus musculus
metabolism both DNMT3A and DNMT3B are involved in de novo DNA methylation Homo sapiens