Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-aza-2'-deoxycytidine | - |
Haemophilus parainfluenzae | |
5-aza-2'-deoxycytidine | - |
Homo sapiens | |
6-thioguanine | incorporation of 6-thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. Presence of 6-thioguanine at the unmethylated CpG site abolished almost completely the methylation of its 5' adjacent cytosine by HpaII | Haemophilus parainfluenzae | |
6-thioguanine | incorporation of 6-thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. Presence of 6-thioguanine at the unmethylated CpG site abolished almost completely the methylation of its 5' adjacent cytosine by DNMT1 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA + S-adenosyl-L-methionine | Homo sapiens | - |
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? | |
DNA + S-adenosyl-L-methionine | Haemophilus parainfluenzae | - |
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Haemophilus parainfluenzae | - |
- |
- |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
JURKAT cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA + S-adenosyl-L-methionine | - |
Homo sapiens | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? | |
DNA + S-adenosyl-L-methionine | - |
Haemophilus parainfluenzae | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? | |
DNA + S-adenosyl-L-methionine | double-stranded DNA substrates with CpG site containing 8-oxo-7,8-dihydroguanine, resulting in diminished enzymatic methylation of its 5' neighboring cytosine, or 8-oxoG or O6-methylguanine in the CpG site, overview | Homo sapiens | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? | |
DNA + S-adenosyl-L-methionine | double-stranded DNA substrates with CpG site, overview | Haemophilus parainfluenzae | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Dnmt1 | - |
Homo sapiens |
HpaII | - |
Haemophilus parainfluenzae |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
65 | - |
20 min, inactivation | Homo sapiens |
65 | - |
20 min, inactivation | Haemophilus parainfluenzae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Homo sapiens | |
S-adenosyl-L-methionine | - |
Haemophilus parainfluenzae |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme activity is involved in the epigenetic pathway of gene regulation | Homo sapiens |
physiological function | the enzyme activity is involved in the epigenetic pathway of gene regulation | Haemophilus parainfluenzae |