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Literature summary for 2.1.1.37 extracted from
- 6-Thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo (2009), Biochemistry, 48, 2290-2299.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-aza-2'-deoxycytidine | - |
Haemophilus parainfluenzae |  |
| 5-aza-2'-deoxycytidine | - |
Homo sapiens | |
| 6-thioguanine | incorporation of 6-thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. Presence of 6-thioguanine at the unmethylated CpG site abolished almost completely the methylation of its 5' adjacent cytosine by HpaII | Haemophilus parainfluenzae | |
| 6-thioguanine | incorporation of 6-thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. Presence of 6-thioguanine at the unmethylated CpG site abolished almost completely the methylation of its 5' adjacent cytosine by DNMT1 | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA + S-adenosyl-L-methionine | Homo sapiens | - |
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? | |
| DNA + S-adenosyl-L-methionine | Haemophilus parainfluenzae | - |
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Haemophilus parainfluenzae | - |
- |
- |
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| JURKAT cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA + S-adenosyl-L-methionine | - |
Homo sapiens | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? | |
| DNA + S-adenosyl-L-methionine | - |
Haemophilus parainfluenzae | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? | |
| DNA + S-adenosyl-L-methionine | double-stranded DNA substrates with CpG site containing 8-oxo-7,8-dihydroguanine, resulting in diminished enzymatic methylation of its 5' neighboring cytosine, or 8-oxoG or O6-methylguanine in the CpG site, overview | Homo sapiens | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? | |
| DNA + S-adenosyl-L-methionine | double-stranded DNA substrates with CpG site, overview | Haemophilus parainfluenzae | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Dnmt1 | - |
Homo sapiens |
| HpaII | - |
Haemophilus parainfluenzae |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 65 | - |
20 min, inactivation | Homo sapiens |
| 65 | - |
20 min, inactivation | Haemophilus parainfluenzae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| S-adenosyl-L-methionine | - |
Homo sapiens | |
| S-adenosyl-L-methionine | - |
Haemophilus parainfluenzae | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme activity is involved in the epigenetic pathway of gene regulation | Homo sapiens |
| physiological function | the enzyme activity is involved in the epigenetic pathway of gene regulation | Haemophilus parainfluenzae |
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