Cloned (Comment) | Organism |
---|---|
expression in Sf9 cell | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
K+ | Dnmt3b | Mus musculus | |
Mg2+ | 1 mM, slight inhibition, Dnmt3a; 1 mM, slight inhibition, Dnmt3b | Mus musculus | |
Mn2+ | strong inhibition, Dnmt3a; strong inhibition, Dnmt3b | Mus musculus | |
additional information | Dnmt3a is fully active at physiological potassium concentration of K+ | Mus musculus | |
NaCl | Dnmt3a, inhibits activity around physiological ionic strength; Dnmt3b, inhibits activity around physiological ionic strength | Mus musculus | |
Ni2+ | strong inhibition, Dnmt3a; strong inhibition, Dnmt3b | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0003 | - |
S-adenosyl-L-methionine | pH 7.4, 37°C, Dnmt3a | Mus musculus | |
0.0004 | - |
dIdC | pH 7.4, 37°C, Dnmt3b | Mus musculus | |
0.0005 | - |
dGdC | pH 7.4, 37°C, Dnmt3b | Mus musculus | |
0.0007 | - |
S-adenosyl-L-methionine | pH 7.4, 37°C, Dnmt3b | Mus musculus | |
0.0012 | - |
dIdC | pH 7.4, 37°C, Dnmt3b | Mus musculus | |
0.0016 | - |
dGdC | pH 7.4, 37°C, Dnmt3b | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + DNA | Mus musculus | the enzyme is a de novo-type DNA methyltransferase | S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | O88508 | Dnmt3a | - |
Mus musculus | O88509 | Dnmt3b | - |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | no activity with CpT and CpC | Mus musculus | ? | - |
? | |
additional information | scarcely methylates CpC | Mus musculus | ? | - |
? | |
S-adenosyl-L-methionine + CpA | - |
Mus musculus | S-adenosyl-L-homocysteine + CpA containing 5-methylcytosine | - |
? | |
S-adenosyl-L-methionine + CpG | - |
Mus musculus | S-adenosyl-L-homocysteine + CpG containing 5-methylcytosine | - |
? | |
S-adenosyl-L-methionine + CpT | - |
Mus musculus | S-adenosyl-L-homocysteine + CpT containing 5-methylcytosine | - |
? | |
S-adenosyl-L-methionine + dGdC | - |
Mus musculus | ? | - |
? | |
S-adenosyl-L-methionine + dIdC | - |
Mus musculus | ? | - |
? | |
S-adenosyl-L-methionine + DNA | the enzyme is a de novo-type DNA methyltransferase | Mus musculus | S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine | - |
? | |
S-adenosyl-L-methionine + DNA | poly(dGdC)-poly(dGdC) or poly(dIdC)-poly(dIdC) | Mus musculus | S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Dnmt3a | - |
Mus musculus |
DNMT3B | - |
Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | 7.8 | Dnmt3b | Mus musculus |
7 | 7.8 | Dnmt3a | Mus musculus |