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Literature summary for 2.1.1.37 extracted from

  • Aubol, B.E.; Reich, N.O.
    Murine DNA cytosine C(5)-methyltransferase: in vitro studies of de novo methylation spreading (2003), Biochem. Biophys. Res. Commun., 310, 209-214.
    View publication on PubMed
Search for more literature for 2.1.1.37

Activating Compound

Activating Compound Comment Organism Structure
5-methyl cytosine preference for single stranded DNA substrates is increased up to 50fold by the presence of a proximal 5-methyl cytosine. This modulation is distance-dependent and is due to an enhanced binding affinity and minor changes in catalytic efficiency. No modulation of activity is observed with double stranded DNA Mus musculus
additional information no modulation of catalytic activity in response to 5-methyl cytosine Spirulina sp.

Organism

Organism UniProt Comment Textmining
Mus musculus P13864
-
-
Spirulina sp.
-
-
-
Spirulina sp. MW-1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + DNA
-
 Spirulina sp. S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
 ?
S-adenosyl-L-methionine + DNA preference for single stranded DNA substrates is increased up to 50fold by the presence of a proximal 5-methyl cytosine. This modulation is distance-dependent and is due to an enhanced binding affinity and minor changes in catalytic efficiency. No modulation of activity is observed with double stranded DNA Mus musculus S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
 ?
S-adenosyl-L-methionine + DNA
-
 Spirulina sp. MW-1 S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
 ?

Synonyms

Synonyms Comment Organism
DNA cytosine C(5)-methyltransferase
-
 Mus musculus
Dnmt1
-
 Mus musculus
M.SssI
-
 Spirulina sp.